(Amlodipine + Olmesartan Medoxomil)-(5mg+20mg) is used in the treatment of Hypertension (high blood pressure).
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Duopres 5/20mg Tablet is a combination medication used to treat high blood pressure. It contains Olmesartan (angiotensin receptor blocker) and Amlodipine (calcium channel blocker). Olmesartan relaxes blood vessels by blocking angiotensin, while Amlodipine relaxes blood vessels and reduces the heart's workload.
You can take Duopres 5/20mg Tablet with or without food, as advised by your doctor. Common side effects include headaches, drowsiness, ankle swelling, nausea, and dizziness. It's important not to stop the medication abruptly; consult your doctor for guidance.
Inform your doctor about your medical history, especially kidney, liver, heart issues, or diabetes. Duopres 5/20mg Tablet is not recommended during pregnancy or for children under 12. Avoid it if you have low blood pressure or cardiogenic shock. Grapefruit juice and St. John's wort should be avoided.
Although there is no known interaction with alcohol along with Duopres 5/20mg Tablet. However, consuming alcohol when you have a blood pressure problem is not advisable as alcohol can lower blood pressure.
Duopres 5/20mg Tablet is not recommended for use during early pregnancy and should be avoided when more than 3 months pregnant, as it has the potential to cause significant harm to the developing baby. If you are pregnant or planning to become pregnant, it's crucial to consult your doctor before considering the use of Duopres 5/20mg Tablet to ensure the safety of both you and your baby.
Duopres 5/20mg Tablet may pass into breast milk in small amounts and it is not recommended for use in breastfeeding women. Your doctor may choose another treatment if you wish to breastfeed especially if your baby is a newborn or born prematurely. Consult your doctor before taking Duopres 5/20mg Tablet.
Do not drive or operate any tools or machines if you experience dizziness, sleepiness, or headache after taking Duopres 5/20mg Tablet.
Duopres 5/20mg Tablet should be used with caution if you have kidney problems as this medicine may alter kidney functions. Your doctor may suggest tests to closely monitor your kidney function or adjust the dose based on your clinical condition.
Duopres 5/20mg Tablet is broken down in the liver. Hence, this medicine should be used with caution if you have liver problems as it may increase the risk of liver damage. Your doctor may suggest tests to monitor your liver functions and/or recommend dose adjustments based on your clinical condition.
Duopres 5/20mg Tablet is a combination of Amlodipine and Olmesartan.
Common side effects of Duopres 5/20mg Tablet include dizziness, headache, swelling in hands/feet, tiredness, bronchitis, sore throat, runny nose, cough, nausea, diarrhea, constipation, joint or bone pain, back pain, urinary tract infections, chest pain, flu-like symptoms, visual disturbances, and difficulty breathing.
Less common side effects encompass dizziness upon standing, lack of energy, tingling/numbness in hands/feet, vertigo, awareness of heartbeat, fast heartbeat, low blood pressure symptoms, cough, vomiting, dry mouth, upper abdominal pain, skin rash, cramps, pain in arms/legs, increased urge to urinate, sexual inactivity, and difficulty with erection.
Rare side effects involve fainting, severe allergic reactions, redness/warmth in the face, red and itchy bumps, and swelling of the face. Seek medical help immediately if you experience severe allergic reactions, signs of hypotension, severe persistent diarrhea with weight loss, or jaundice-like symptoms.
Hypertension or high blood pressure is a condition in which the force exerted by the circulating blood on the walls of the blood vessel is high. Duopres 5/20mg Tablet is used to control high blood pressure.
Amlodipine, a dihydropyridine calcium channel blocker, primarily affects vascular smooth muscle cells by reducing the flow of calcium ions through their membranes. This leads to vasodilation in peripheral arterial vasculature, lowering peripheral vascular resistance and blood pressure. Amlodipine's impact on vascular smooth muscle cells is more significant compared to its effect on cardiomyocytes.
Angiotensin II, a potent vasoconstrictor and key hormone in the renin-angiotensin system, is generated from angiotensin I via the action of angiotensin-converting enzyme (ACE). It plays a crucial role in the pathophysiology of hypertension and stimulates the adrenal cortex to release aldosterone.
Olmesartan medoxomil works by specifically inhibiting the binding of angiotensin II to AT1 receptors, present in various tissues such as vascular smooth muscle and adrenal glands. This inhibition leads to reduced vasoconstriction and aldosterone secretion. Olmesartan medoxomil is a competitive and reversible AT1 receptor antagonist, demonstrated through in vitro binding studies. Unlike ACE inhibitors, olmesartan medoxomil does not interfere with ACE (kinase II), which converts angiotensin I to angiotensin II and also breaks down bradykinin.
For patients who are currently taking Amlodipine and Olmesartan Medoxomil individually and need a substitute, the components can be titrated as follows:
Take Duopres 5/20mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of Duopres 5/20mg Tablet for you depending on your age, body weight, and disease condition.
Duopres 5/20mg Tablet can interact with several medications:
Drug-Drug Interactions:
Drug-Food Interactions:
Drug-Disease Interactions:
The pregnancy category for the combination of amlodipine and olmesartan medoxomil is "D." This means that there is evidence of risk to the fetus, and the use of this combination should be avoided during the second and third trimesters of pregnancy due to the potential for fetal mortality. If pregnancy is detected, this combination should be discontinued as soon as possible.
Both olmesartan and amlodipine are not known to be excreted in human milk. However, due to the potential risk of harm to the nursing child, a decision should be made whether to discontinue breastfeeding or to discontinue taking the medicine, considering the benefits of the medication for the mother.
Store it in a cool and dry place away from light and moisture. Keep it out of the reach of children and pets.
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